Hypidone hydrochloride

SKU: orb1303959

Description

Hypidone hydrochloride (YL0919) is a novel, dual-acting small molecule antidepressant candidate. It functions as both a selective serotonin reuptake inhibitor (SSRI) and a 5-HT1A receptor agonist. This compound is utilized in preclinical research for investigating depression mechanisms and antidepressant efficacy in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1339058-04-6
• MW: 334.84
• Purity: 99.97%
• Formula: C₁₈H₂₃ClN₂O₂
• SMILES: Cl.OC1(Cn2ccccc2=O)CCN(Cc2ccccc2)CC1
• Target: 5-HT Receptor
• Solubility: DMSO:30 mg/mL (89.6 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (5.97 mM)

Bioactivity

• Target IC50:
  Human recombinant cells:1.93±0.18 nM|5-HT uptake (rat cerebral cortical synaptosomes):1.78±0.34 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-HT, 5HT Receptor, 5-hydroxytryptamine Receptor, 5HTReceptor, 5-HT Receptor, 5-HT1A, Hypidone, Hypidone Hydrochloride, Hypidone hydrochloride, inhibit, Inhibitor, YL 0919, YL0919, YL-0919, Serotonin Receptor

Compound Identifiers

PubChem CID

122412736