Hyperforin dicyclohexylammonium salt

SKU: orb1220198

Description

Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt shows antidepressant effect

Key Properties

• CAS Number: 238074-03-8
• MW: 718.1
• Purity: >98% (HPLC)
• Formula: C₄₇H₇₅NO₄
• SMILES: CC(C)C([C@@]12[C@@](C)([C@H](C[C@](C/C=C(C)/C)(C(C(C/C=C(C)/C)=C2O)=O)C1=O)C/C=C(C)/C)CC/C=C(C)/C)=O.C3(CCCCC3)NC4CCCCC4
• Solubility: DMSO : 50 mg/mL (69.63 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: IMQ-induced psoriasis-like mice model. Dosage: 5 mg/kg. Administration: Intraperitoneal injection; once daily for 7 days. Result: Significantly ameliorated skin lesion throughout the treatment period, demonstrated by the reduced severity score of skin inflammation. Suppressed infiltration of CD3+ T cells and down regulated expression of Il1, Il6, Il23, Il17a, Il22, antimicrobial peptides (AMPs) in the skin lesion.
• In Vitro:
  Western blot analysis. Cell line: HaCaT cells. Concentration: 0.1, 1, 10 μM; with or without 10, 20 ng/mL TNF-α Incubation time: 2 hours. Result: Reduced the expressions of p-p38, p-ERK, p-JNK, and p-STAT3, especially at the dosage of 10 μM.

Storage & Handling

• Storage: Store at -20℃
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hyperforin DCHA

Hyperforin dicyclohexylammonium salt: CAS No. 238074-03-8

Compound Identifiers

PubChem CID

46926346