Hyoscyamine sulfate hydrate

SKU: orb1221948

Description

Hyoscyamine Sulfate is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits anticholinergic activity. Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as well as the eye, heart, bladder, and gastrointestinal tract. These inhibitory effects cause a decrease in saliva, bronchial mucus, gastric juices, and sweat. Furthermore, its inhibitory action on smooth muscle prevents bladder contraction and decreases gastrointestinal motility.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 620-61-1
• MW: 387.44
• Purity: >98% (HPLC)
• Formula: C₁₇H₂₅NO₇S
• SMILES: CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.OS(=O)(=O)O
• Target: muscarinic receptor
• Solubility: In Vitro: DMSO : 25 mg/mL (73.87 mM)

Bioactivity

• In Vivo:
  L-Hyoscyamine sulfate (Daturine sulfate; 5-20 mg/kg; iv) prolongs the migrating MMC cycle length. Animal model: Rats. Dosage: 5, 10, 20 mg/kg. Administration: IV. Result: Prolonged the migrating myoelectric complex (MMC) cycle length.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

muscarinic receptor