Hydroxysafflor yellow A

SKU: orb1224006

Description

Hydroxysafflor yellow A inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacity and inhibiting the expression of TGF-β. It prevents steroid-induced avascular necrosis of femoral head by inhibiting primary bone marrow-derived mesenchymal stromal cells. Also, Hydroxysafflor yellow A has anti-tumor effects.

Key Properties

• CAS Number: 78281-02-4
• MW: 612.53338
• Purity: >98% (HPLC)
• Formula: C₂₇H₃₂O₁₆
• SMILES: O=C1C([C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)=C(O)C(O)([C@H]3[C@@H]([C@H]([C@@H]([C@@H](CO)O3)O)O)O)C(O)=C1C(/C=C/C4=CC=C(O)C=C4)=O
• Target: TGFBR
• Solubility: Pyridine, Methanol, Ethanol

Bioactivity

• In Vivo:
  Animal model: Liver injury model induced by alcohol. Dosage: 2.5 or 10 mg/kg. Administration: i.p. daily for 6 weeks. Result: Decreased the level of ALT and AST. Decreased the levels of HA, LN, and III-C. Increased the activities of SOD and GPx and decreased the level of TGF-β1 expression. Animal model: Chronic obstructive pulmonary disease (COPD). Dosage: 30, 48, 76.8 mg/kg. Administration: i.p. Result: Inhibited the elevated IL-6, IL-1β, TNF-α, ICAM-1 and VCAM-1 mRNA Levels. Inhibited the increased phosphorylation and NF-κB p65 levels.
• In Vitro:
  Cell Migration Assay Cell line: VSMCs. Concentration: 0.1, 1, 10, 100 μM Incubation time: 24 h. Result: Inhibited LPS-induced VSMCs proliferation and migration with the concentration of 10 μM. Western blot analysis. Cell line: VSMCs. Concentration: 10 μM. Incubation time: 24 h. Result: Inhibited LPS-induced upregulation of pro-inflammatory factors (TNF-α, IL-6, and IL-8). Inhibited LPS-induced upregulation of TLR-4 and activation of Rac1/Akt pathway. Cell Viability Assay Cell line: 3T3-L1. Concentration: 0.01, 0.1, 1, 10 mg/L Incubation time: 4, 8, 24, 48, 72, 96 h. Result: Inhibit the cell viability in a dose and time-dependent manner. Apoptosis Analysis Cell line: HepG2, Huh7. Concentration: 20, 40, 80, 160 μM. Incubation time: 24 h. Result: Suppressed the growth and induced apoptotic cell death in both concentration and time-dependent manners.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hydroxysafflor yellow A | Safflomin A

Quick Database Links

Gene Symbol

TGFBR