α-Hydroxyglutaric Acid Lithium

SKU: orb1945028

Description

α-Hydroxyglutaric Acid Lithium is a metabolite derived from glutamate that acts as an inhibitor of α-ketoglutarate-dependent dioxygenases, including TET family 5-methylcytosine hydroxylases. It is widely used in research to study epigenetic regulation, oncometabolism, and cellular signaling pathways such as mTOR in both cellular and animal models.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• MW: 159.98
• Purity: 99.96% (May vary between batches)
• Formula: C₅H₆Li₂O₅
• SMILES: O=C(CCC(C([O-])=O)O)[O-].[Li+].[Li+]
• Target: Decarboxylase,mTOR,Endogenous Metabolite
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  α-Hydroxyglutaric Acid Lithium inhibits the activity of multiple histone demethylases. In the active site of histone demethylases, α-Hydroxyglutaric Acid Lithium occupies the same space as α-KG, leading to inhibition of their activity. Additionally, α-Hydroxyglutaric Acid Lithium inhibits the activity of TET 5-methylcytosine hydroxylases.Treatment of U-87MG cells with α-Hydroxyglutaric Acid Lithium at concentrations ranging from 10 to 50 mM results in increased levels of HIF-1α and decreased levels of endostatin.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

histidine decarboxylase, mTOR, EndogenousMetabolite, Endogenous Metabolite, α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base), αHydroxyglutaricAcidLithium(2889318Freebase)

Compound Identifiers

PubChem CID

171360487