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Hydroxyfasudil

SKU: orb1302996

Description

Hydroxyfasudil is a potent and selective inhibitor of ROCK1 and ROCK2 kinases, exhibiting IC50 values of 0.73 and 0.72 μM, respectively. It is widely used in cardiovascular and neurological research to investigate Rho/ROCK pathway mechanisms in both cellular and animal models of hypertension, vasospasm, and stroke.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number105628-72-6
MW307.37
Purity98.79% (May vary between batches)
FormulaC14H17N3O3S
SMILESO=c1[nH]ccc2c(cccc12)S(=O)(=O)N1CCCNCC1
TargetROCK,PKA
Solubility10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.63 mM);DMSO:31 mg/mL (100.86 mM)

Bioactivity

Target IC50
ROCK2:0.72 μM|ROCK1:0.73 μM|PKA:37 μM

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, HA1100, HA-1100, HA 1100, Hydroxyfasudil, Hydroxy-Fasudil, Inhibitor, PKA, ROK, ROCK, ROCK1, ROCK2, Rho-kinase, Rho-associated kinase, Rho-associated protein kinase

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

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5 mg
$ 80.00
1 ml x 10 mM (in DMSO)
$ 80.00
10 mg
$ 100.00
25 mg
$ 140.00
50 mg
$ 200.00
100 mg
$ 290.00
DispatchUsually dispatched within 5-10 working days
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