Hydroxycitric acid tripotassium hydrate

SKU: orb1309565

Description

Potassium citrate monohydrate, a derivative of citric acid and key component of Garcinia cambogia, acts as an ATP-citrate lyase inhibitor. It is applied in research exploring nephrolithiasis prevention, metabolic studies for weight management, and investigations into its HIF-inhibitory, antioxidant, and anti-inflammatory properties in cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 6100-05-6
• MW: 324.41
• Purity: 95.00%
• Formula: C₆H₇K₃O₈
• SMILES: O.[K+].[K+].[K+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
• Target: Apoptosis,ATP Citrate Lyase,HIF/HIF Prolyl-Hydroxylase,Antibacterial,Endogenous Metabolite,HIF
• Solubility: DMSO:2.49 mg/mL (7.68 mM)

Bioactivity

• In Vivo:
  Hydroxycitric acid attenuates the oxidative stress induced by calcium oxalate crystallization. Hydroxycitric acid has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. Moreover, Hydroxycitric acid alleviates tubular injury and apoptosis caused by calcium oxalate crystals. The administration of Hydroxycitric acid can suppress body weight gain and fat accumulation in animals. Hydroxycitric acid (100-200 mg/kg) treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). Calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Hydroxycitric acid is significantly decreased.
• In Vitro:
  Hydroxycitric acid suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells. Hydroxycitric acid decreases the accumulation of lipid droplets and accelerated energy metabolism in chicken hepatocytes. Hydroxycitric acid protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions.Hydroxycitric acid shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Hydroxycitric acid can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ACLY, 1534146, ATPCitrateLyase, ATP, ATP Citrate Lyase, ATP citrate lyase, anti-inflammation, antioxidation, Bacterial, cleavage, CaOx, Citrate, inhibit, extramitochondrial, Hypoxia-inducible factors, Hydroxycitric acid tripotassium, Hydroxycitric acid tripotassium hydrate, Hydroxycitric acid tripotassium Hydrate, Inhibitor, HIFs, HIFProlylHydroxylase, HIF, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF-PH, HIF-1α, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, Potassium citrate, Potassium Citrate, Potassium citrate Monohydrate, Potassium citrate monohydrate, stones, safety

Compound Identifiers

PubChem CID

2735208