Hydroxycitric acid tripotassium hydrate

SKU: orb1309565

Description

Hydroxycitric acid tripotassium hydrate

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 6100-05-6
• MW: 324.41
• Purity: 95.00%
• Formula: C₆H₇K₃O₈
• SMILES: O.[K+].[K+].[K+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
• Target: Endogenous Metabolite,HIF/HIF Prolyl-Hydroxylase,Antibacterial,HIF,ATP Citrate Lyase
• Solubility: DMSO:2.49 mg/mL (7.68 mM)

Bioactivity

• In Vivo:
  Hydroxycitric acid attenuate the oxidative stress induced by calcium oxalate crystallization. Hydroxycitric acid has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. Moreover, Hydroxycitric acid alleviates tubular injury and apoptosis caused by calcium oxalate crystals the administration of Hydroxycitric acid can suppress body weight gain and fat accumulation in animals. Hydroxycitric acid (100-200 mg/kg) treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). Calcium oxalate crystal deposition in mice Male C57BL/6J mice) treated with Hydroxycitric acid is significantly decreased.
• In Vitro:
  Hydroxycitric acid suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells. Hydroxycitric acid decrease the accumulation of lipid droplets and accelerated energy metabolism in chicken hepatocytes. Hydroxycitric acid protect the cells from ER stress by increasin the antioxidant status and mitochondrial functions.Hydroxycitric acid shows an HIF inhibitory effect compared wit the control group in ARPE19 cells and 661W cells. Hydroxycitric acid can downregulate Hif1a an the downstream genes in ARPE19 cells and 661W cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

ACLY, 1534146, ATPCitrateLyase, ATP, ATP Citrate Lyase, ATP citrate lyase, anti-inflammation, antioxidation, Bacterial, cleavage, CaOx, Citrate, inhibit, extramitochondrial, Hypoxia-inducible factors, Hydroxycitric acid tripotassium, Hydroxycitric acid tripotassium hydrate, Hydroxycitric acid tripotassium Hydrate, Inhibitor, HIFs, HIFProlylHydroxylase, HIF, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF-PH, HIF-1α, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF/HIFProlylHydroxylase, Potassium citrate, Potassium Citrate, Potassium citrate Monohydrate, Potassium citrate monohydrate, stones, safety

Compound Identifiers

PubChem CID

2735208