Hydroxy-PP-Me

SKU: orb2277599

Description

Hydroxy-PP-Me is a selective carbonyl reductase 1 (CBR1) inhibitor that blocks apoptosis triggered by serum deprivation. This compound is a valuable research tool for studying leukemia, with applications in both in vitro cell culture models and in vivo experimental systems to investigate CBR1's role in cancer cell survival.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 833481-77-9
• MW: 282.34
• Purity: 99.92% (May vary between batches)
• Formula: C₁₆H₁₈N₄O
• SMILES: OC1=CC=CC(=C1)C2=CN(C=3N=CN=C(NC)C32)C(C)C
• Target: ROS,Apoptosis,NADPH
• Solubility: DMSO:80 mg/mL (283.35 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.69 mM)

Bioactivity

• Target IC50:
  CBR1:759 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, CBR1

Compound Identifiers

PubChem CID

11243030