Hydroxy bosentan

SKU: orb1987493

Description

Hydroxy bosentan (Ro 48-5033) is the primary active metabolite of the endothelin receptor antagonist bosentan, formed via hepatic CYP450 metabolism. It retains approximately 10-20% of the parent drug's pharmacological activity. This metabolite is utilized in research applications investigating bosentan's pharmacokinetics, metabolic pathways, and comparative efficacy in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 253688-60-7
• MW: 567.61
• Formula: C₂₇H₂₉N₅O₇S
• SMILES: O=S(=O)(NC=1N=C(N=C(OCCO)C1OC=2C=CC=CC2OC)C3=NC=CC=N3)C4=CC=C(C=C4)C(C)(C)CO
• Target: Endogenous Metabolite,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

6426755