hydrocotarnine

SKU: orb1298160

Description

hydrocotarnine

Research Area

Immunology & Inflammation, Protein Biochemistry

Key Properties

• CAS Number: 550-10-7
• MW: 221.25
• Purity: 98.85%
• Formula: C₁₂H₁₅NO₃
• SMILES: COC1=C2CN(C)CCC2=CC2=C1OCO2
• Target: Others,E1/E2/E3 Enzyme,Interleukin
• Solubility: DMSO:55 mg/mL (248.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (9.04 mM)

Bioactivity

• In Vivo:
  In vivo, inhibition of Cbl with an analgesic drug, hydrocotarnine, increases inflammasome-mediated IL-18 secretion in the colon, and protects mice from dextran sulphate sodium-induced colitis. Together, our novel findings provide new insights into the role of the SFK-Cbl axis in suppressing NLRP3 inflammasome activation and identify a novel clinical utility of hydrocortanine for disease treatment.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cancer pain, Cbl, cellular glucose uptake, E3 ligating enzyme, E1 activating enzyme, E1/E2/E3 Enzyme, E2 conjugating enzyme, NLRP3, inflammasome activation, inhibit, glycolytic capacity, glycolytic metabolism, GLUT1, hydrocotarnine, IL-18, IL-1β, Inhibitor, Ubiquitin activating enzyme, Ubiquitin conjugating enzyme, Ubiquitin ligase

Compound Identifiers

PubChem CID

3646