Hydrocortisone 21-hemisuccinate

SKU: orb1222506

Description

Hydrocortisone hemisuccinate anhydrous is an anti-inflammatory agent.(In Vitro):Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.(In Vivo):Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	2203-97-6
MW	462.53
Purity	>98% (HPLC)
Formula	C₂₅H₃₄O₈
SMILES	[H][C@@]12CC[C@](O)(C(=O)COC(=O)CCC(O)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Target	Others
Solubility	In Vitro: DMSO : 250 mg/mL (540.51 mM)

Bioactivity

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In Vivo

Hydrocortisone hemisuccinate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice. Animal model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis. Dosage: 30 mg/kg. Administration: p.o. twice daily for 5 days. Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group. Increased the body weight.

In Vitro

Hydrocortisone hemisuccinate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells. Hydrocortisone hemisuccinate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Hydrocortisone hemisuccinate anhydrous

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