Hydrangeic acid

SKU: orb3179678

Description

Hydrangeic acid is an orally effective stilbene-type glycolipid metabolism regulator that lowers blood glucose and lipids. This compound can be isolated from processed leaves of Hydrangea macrophylla var. thunbergii. It is linked to glucose-lipid metabolism and insulin sensitivity regulation. Hydrangeic acid does not directly activate PPARγ or PPARα; instead, it enhances the mRNA expression of adiponectin, PPARγ2, GLUT4, and fatty acid-binding protein aP2 while reducing TNF-α mRNA levels, thereby promoting adipogenesis, glucose uptake, and GLUT4 translocation in 3T3-L1 cells. Additionally, it suppresses the production of NO induced by inflammatory factors, improving insulin resistance. Hydrangeic acid is useful for research related to type 2 diabetes and does not cause liver weight gain.

Key Properties

• CAS Number: 491-79-2
• MW: 256.26
• Formula: C₁₅H₁₂O₄
• SMILES: C(=C/C1=CC=C(O)C=C1)\C2=C(C(O)=O)C(O)=CC=C2
• Target: transporter,PPAR,TNF

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

transporter,PPAR,TNF