α-Humulene

SKU: orb1297468

Description

α-Humulene

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 6753-98-6
• MW: 204.35
• Purity: 97.18%
• Formula: C₁₅H₂₄
• SMILES: C\C1=C/CC(C)(C)\C=C\C\C(C)=C\CC1
• Target: NOS,NO Synthase,TNF,COX
• Solubility: Ethanol:Soluble;10% DMSO+90% Corn Oil:2.5 mg/mL (12.23 mM);DMSO:50 mg/mL (244.68 mM);Ether:Soluble

Bioactivity

• In Vitro:
  S. officinalis essential oil was obtained by hydrodistillation and fractionated with column chromatography the essential oil and its fractions were analyzed by gas chromatography (GC) coupled to mass spectrometry (MS) the cytotoxic activity was evaluated in cellular lines of breast cancer MCF-7, colon cancer HCT-116, and murine macrophage RAW264.7 cell lines b the MTT assay Results the sub-subfraction F1.1.1 of S. officinalis essential oil containing alpha-humulene present highest activity on RAW264.7 and HCT-116 with IC(50) Values of 41.9 and 77.3 mu g/ml, respectively the sub-subfraction F1.2.1 of S. officinalis essential oil with trans-caryophyllene(Alpha-caryophyllene) showed less activity on RAW246.7 and HCT-116 with IC(50) Values of 90.5 and 145.8 mu g/ml.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Cyclooxygenase, COX, a-Humulene, alpha-Humulene, Alpha-caryophyllene, a-caryophyllene, Humulene, iNOS, Inhibitor, NO Synthase, Nitric oxide synthases, inhibit, NOS, TNF-α, α-Caryophyllene, α-caryophyllene, α Humulene, αHumulene, α-Humulene

Compound Identifiers

PubChem CID

5281520