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Humantenmine

SKU: orb1221754

Description

Humantenmine is a toxic compound isolated from Gelsemium elegans Benth. Humantenmine and koumine may inhibit several CYP450 enzyme activities.

Images & Validation

Key Properties

CAS Number82354-38-9
MW326.39
Purity>98% (HPLC)
FormulaC19H22N2O3
SMILESCCC1=NC2CC3(C4CC1C2CO4)C5=CC=CC=C5N(C3=O)OC
TargetBeta Amyloid
SolubilityIn Vitro: DMSO : 100 mg/mL (306.38 mM)

Bioactivity

In Vitro
Humantenmine (HMT) decreases the 14-day survival rate of the mice to 17% after they are intragastrically treated with HMT, along with hepatic injury and increasing alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels. CYP3A4/5 mediates the metabolism and detoxification of HMT.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

Humantenmine (orb1221754)

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Available Sizes

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100 mg
200 mg
500 mg
5 mg
$ 270.00
10 mg
$ 390.00
25 mg
$ 630.00
50 mg
$ 910.00