Human TREM2 (19-157) Protein, Fc Tag

SKU: orb3158273

Description

Triggering Receptor Expressed on Myeloid cells 2 (TREM2) is a pivotal cell-surface receptor primarily found on microglia in the brain and macrophages in peripheral tissues. Acting as a lipid and amyloid-beta sensor, it signals through the adapter protein DAP12 to regulate immune responses, cell survival, and phagocytosis. In neurobiology, TREM2 is a major focus because its dysfunction is strongly linked to Alzheimer’s disease progression and impaired clearance of neurotoxic plaques.

Research Area

Neuroscience

Images & Validation

• Application Notes:
  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 42.1 kDa. The protein migrates as 50-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Expression System: HEK293
• Target: TREM2
• Reactivity: Human
• Tag: C-Fc
• Expression Region: His 19 - His 157
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated
• MW: 42.1 kDa
• Purity: 90%

Storage & Handling

• Storage: -20°C
• Form/Appearance: Powder
• Buffer/Preservatives: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

TREM2

RefSeq:Q9NZC2