Human NME1 Protein, His Tag

SKU: orb257714

Description

Nucleoside diphosphate kinase A, a member of the NDK family, is also known as NME1, NDP kinase A (NDPA), granzyme A-activated DNase (GAAD), metastasis inhibition factor nm23 (NM23-H1) and tumor metastatic process-associated protein. NME1 plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 is also involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Furthermore, NME1 is required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, NME1 works in concert with TREX1. NME1 nicks one strand of D and TREX1 removes bases from the free 3' end to enhance D damage and prevent D end reannealing and rapid repair.

Images & Validation

• Application Notes:
  This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.0 kDa. The protein migrates as 17-18 kDa under reducing (R) condition (SDS-PAGE).

Key Properties

• Expression System: E. coli
• Target: NME1
• Reactivity: Human
• Tag: N-6×His
• Expression Region: Ala 2 - Glu 152
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated
• MW: 18.0 kDa
• Purity: 98%

Storage & Handling

• Storage: -20°C
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

SDS-PAGE analysis of Human NME1 protein

Quick Database Links

Gene Symbol

NME1

UniProt

AAH00293

RefSeq:AAH00293