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Human NME1 Protein, His Tag
Catalog Number: orb257714
| Catalog Number | orb257714 |
|---|---|
| Category | Proteins |
| Description | Nucleoside diphosphate kinase A, a member of the NDK family, is also known as NME1, NDP kinase A (NDPA), granzyme A-activated DNase (GAAD), metastasis inhibition factor nm23 (NM23-H1) and tumor metastatic process-associated protein. NME1 plays a major role in the synthesis of nucleoside triphosphates other than ATP. NME1 is also involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Furthermore, NME1 is required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, NME1 works in concert with TREX1. NME1 nicks one strand of D and TREX1 removes bases from the free 3' end to enhance D damage and prevent D end reannealing and rapid repair. |
| Target | NME1 |
| Conjugation | Unconjugated |
| Tag | N-6×His |
| Reactivity | Human |
| Form/Appearance | Powder |
| Buffer/Preservatives | PBS, pH 7.4 |
| Purity | 98% |
| Protein Sequence | AAH00293 |
| UniProt ID | P15531 |
| MW | 18.0 kDa |
| Application notes | This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.0 kDa. The protein migrates as 17-18 kDa under reducing (R) condition (SDS-PAGE). |
| Expression System | E. coli |
| Endotoxins | 1.0 EU per μg |
| Biological Origin | Human |
| Expression Region | Ala 2 - Glu 152 |
| Storage | -20°C to -70°C for 12 months in lyophilized state;. -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower |
| Note | For research use only |
| NCBI | AAH00293 |
SDS-PAGE analysis of Human NME1 protein
Recombinant Human NDPKA/NME1 Protein, His Tag [orb1551981]
≥90% as determined by SDS-PAGE
This protein contains the human NME1(Met1-Glu152) was fused with the N-terminal His Tag and expressed in E. coli.
100 μg, 50 μgHuman NME1 Protein, His Tag [orb2700758]
> 98%, determined by SDS-PAGE
This protein contains the human NME1 isoform b (NP_0002601) (Ala 2-Glu 152) was expressed with a polyhistide tag at the N-terminus and expressed from E. coli.
100 μg, 50 μgHuman NME1 Protein, His Tag [orb2697282]
> 98%, determined by SDS-PAGE
This protein contains the human NME1 isoform b (NP_0002601) (Ala 2-Glu 152) was expressed with a polyhistide tag at the N-terminus and expressed from E. coli.
100 μg, 1 mg
