Human interleukin 1β

SKU: orb1729593

Description

This protein is produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. The human IL-1 beta cDNA encodes a 269 aa precursor. A 116 aa propeptide is cleaved intracellularly by the cysteine protease IL-1 beta -converting enzyme (Caspase-1/ICE) to generate the active cytokine. The 17 kDa mature human IL-1 beta shares >80 % aa sequence identity with mouse IL-1 beta

Images & Validation

• Tested Applications: SDS-PAGE
• Application Notes:
  For research use only

Key Properties

• Source: E.coli
• Species/Host: E. coli
• Expression System: Intercellular
• Biological Origin: Recombinant protein expressed as His tage protein in E.coli
• Reactivity: Human, Mouse
• Tag: Histidine
• Molecular Weight: ~17 kDa
• Protein Sequence: APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS
• Purity: ≥98%
• Endotoxins: Not tested
• Conjugation: Unconjugated

Storage & Handling

• Storage: After reconstitution, store at -20°C; Avoid repeated freeze thaw
• Form/Appearance: Lyophilized
• Buffer/Preservatives: No preservative
• Concentration: 1mg/mL
• Hazard Information: For Research use only
• Disclaimer: For research use only

Alternative Names

IL1B, IL1F2