Human IL-22BP Protein, Fc Tag (MALS verified)

• Catalog Number: orb1743040
• Category: Proteins
• Description: This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Isoform 1 may play a role in establishing and maintaining successful pregnancy. Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 90%
• Conjugation: Unconjugated
• MW: 51 kDa
• Target: IL-22BP
• Source: Human IL-22BP Protein, Fc Tag (orb1743040) is expressed from human 293 cells (HEK293). It contains AA Thr 22 - Pro 231 (Accession # Q969J5-2).
• Expression System: HEK293
• Biological Activity: Immobilized Human IL-22, His Tag at 5 μg/mL (100 μL/well) can bind Human IL-22BP Protein, Fc Tag with a linear range of 0.2-10 ng/mL (QC tested).
• Expression Region: Thr 22 - Pro 231
• Endotoxins: 1.0 EU per μg
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: PBS, pH 7.4
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51 kDa. The protein migrates as 65-85 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Immobilized Human IL-22, His Tag (Cat. No. orb545740) at 5 μg/mL (100 μL/well) can bind Human IL-22BP Protein, Fc Tag (Cat. No. orb1743040) with a linear range of 0.2-10 ng/mL (QC tested).