Human GDNF / ATF / hGDNF Protein (E. coli), Research Grade

SKU: orb3158150

Description

Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. The GDNF family members (consists of GDNF, neurturin, artemin and persephin) are structurally similar to transforming growth factor-beta. Unlike other members of the TGF-beta superfamily, which signal through the receptor serine-threonine kinases, GDNF family ligands activate intracellular signalling cascades via the receptor tyrosine kinase Ret. GDNF family ligands binds to GDNF family receptor alpha (GFRalpha) and then the GDNF family ligand-GFR alpha complex binds to and stimulates autophosphorylation of Ret.

Research Area

Infectious Disease & Virology

Images & Validation

• Application Notes:
  This protein carries no "tag". The protein has a calculated MW of 15.2 kDa. The protein migrates as 15 kDa±3 kDa under reducing (R) condition, and 30 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE)

Key Properties

• Expression System: E. coli
• Target: GDNF
• Reactivity: Human
• Tag: Native
• Molecular Weight: 15.2 kDa
• Expression Region: Ser 78 - Ile 211
• Purity: 95%
• Endotoxins: 0.01 EU per μg
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Form/Appearance: Powder
• Buffer/Preservatives: 20 mM Sodium Citrate, 150 mM NaCl, pH 4.0
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GDNF

RefSeq:P39905