Human CXCL1 Protein, Fc Tag

SKU: orb1496298

Description

Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small molecule of cytokines belonging to the CXC chemokine family. Also known as growth-regulated oncogene alpha (Growth-regulated oncogene alpha, GROα). It's also known as keratinocytes-derived chemokine (KC) in mice or cytokine-induced neutrophil chemoattractant type-1 (CINC-1) in rats. In humans, this protein is encoded by the gene Cxcl1 and is located on human chromosome 4 among genes for other CXC chemokines. The chemokine CXCL1 is expressed by macrophages, neutrophils and epithelial cells. The chemokine CXCL1 has a chemotactic effect on neutrophils. CXCL1 binds to the chemokine receptor CXCR2 and plays a role in cell chemotaxis. Human CXCL1 is clustered on chromosome 4 adjacent to many CXC chemokine genes. Major roles of CXCL1 include neovascularization, inflammation, wound healing, and tumorigenesis.

Images & Validation

• Application Notes:
  This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 34.3 kDa. The protein migrates as 37-43 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Expression System: HEK293
• Target: CXCL1
• Reactivity: Human
• Tag: C-Fc
• Molecular Weight: 34.3 kDa
• Expression Region: Ala 35 - Asn 107
• Purity: 95%
• Endotoxins: 1.0 EU per μg
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C to -70°C for 12 months in lyophilized state;. -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CXCL1

UniProt

P09341