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Human Clusterin Protein, His Tag

Catalog Number: orb257350

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$ 540.00
Catalog Numberorb257350
CategoryProteins
DescriptionClusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa N­glycosylated disulfide­linked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mR and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.
TargetClusterin
ConjugationUnconjugated
TagC-6×His
ReactivityHuman
Form/AppearancePowder
Buffer/PreservativesPBS, pH 7.4
Purity95%
Protein SequenceNP_001822.3
UniProt IDP10909
MW50.9 kDa
Application notesThis protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.9 kDa. The protein migrates as 32-40 kDa under reducing (R) condition (SDS-PAGE).
Expression SystemHEK293
Endotoxins1.0 EU per μg
Biological OriginHuman
Expression RegionAsp 23 - Glu 449
Storage-20°C to -70°C for 12 months in lyophilized state;. -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower
NoteFor research use only
NCBINP_001822.3
Human Clusterin Protein, His Tag

SDS-PAGE analysis of Human CLU protein