Human Cathepsin D Protein, His Tag (active enzyme, MALS verified) [Out of stock]

• Catalog Number: orb1939668
• Category: Proteins
• Description: This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Liquid
• Purity: 95%
• Conjugation: Unconjugated
• MW: 44.5 kDa
• Target: Cathepsin D
• Source: Human Cathepsin D Protein, His Tag (CAD-H52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Leu 412 (Accession # P07339-1).
• Expression System: HEK293
• Expression Region: Leu 21 - Leu 412
• Endotoxins: 1.0 EU per μg
• Storage: -70°C
• Buffer/Preservatives: 12.5 mM MES, 75 mM NaCl, pH 6.5
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 44.5 kDa. The protein migrates as 45-50 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.