Human Cathepsin C Protein, His Tag (active enzyme, MALS verified) [Out of stock]

• Catalog Number: orb1939660
• Category: Proteins
• Description: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]
• Reactivity: Human
• Tag: C-10×His
• Form/Appearance: Liquid
• Purity: 95%
• Conjugation: Unconjugated
• MW: 51.4 kDa
• Target: Cathepsin C
• Source: Human Cathepsin C Protein, His Tag (CAC-H52H3) is expressed from human 293 cells (HEK293). It contains AA Asp 25 - Leu 463 (Accession # P53634-1).
• Expression System: HEK293
• Expression Region: Asp 25 - Leu 463
• Endotoxins: 1.0 EU per μg
• Storage: -70°C
• Buffer/Preservatives: 12.5 mM MES, 75 mM NaCl, pH 6.5
• Note: For research use only
• Application notes: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 51.4 kDa. The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.