Human BDNF / Abrineurin Protein (E. coli), Research Grade

SKU: orb3158101

Description

Brain-derived neurotrophic factor (BDNF) along with nerve growth factor (NGF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5) are members of the neurotrophin family of trophic factors. The neurotrophins play essential roles in the development, survival, and function of a wide range of neurons in both the peripheral and central nervous systems. The neurotrophins interact with two cell surface receptors, the low affinity P75 receptor and the Trk family of high affinity tyrosine kinase receptors. NGF preferentially binds TrkA, BDNF and NT4/5 bind TrkB, and NT-3 binds TrkC (and TrkA to a lesser extent).

Research Area

Infectious Disease & Virology; Neuroscience

Images & Validation

• Application Notes:
  This protein carries no "tag". The protein has a calculated MW of 13.6 kDa. The protein migrates as 15 kDa±3 kDa under reducing (R) condition, and 13 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE)

Key Properties

• Expression System: E. coli
• Target: BDNF
• Reactivity: Human
• Tag: Native
• Expression Region: His 129 - Arg 247
• Endotoxins: 0.01 EU per μg
• Conjugation: Unconjugated
• MW: 13.6 kDa
• Purity: 95%

Storage & Handling

• Storage: -20°C
• Form/Appearance: Powder
• Buffer/Preservatives: 0.1% TFA, pH 2.2
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

BDNF

RefSeq:P23560