Human BCAM Protein, His Tag, low Endotoxin (MALS verified)

SKU: orb3123686

Description

Basal Cell Adhesion Molecule (BCAM), also known as the Lutheran blood group glycoprotein, is a transmembrane glycoprotein belonging to the immunoglobulin superfamily (IgSF). Encoded by a gene located on human chromosome 19, BCAM consists of five extracellular immunoglobulin-like (Ig-like) domains, a single transmembrane segment, and a short intracellular tail. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. This molecule plays pivotal roles in multiple physiological processes (e.g., cell-matrix interaction, tissue development) and pathological conditions (e.g., tumor metastasis, hematological disorders).

Images & Validation

• Application Notes:
  This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 58.1 kDa. The protein migrates as 80-95 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Expression System: HEK293
• Target: BCAM
• Reactivity: Human
• Tag: C-10×His
• Molecular Weight: 58.1 kDa
• Expression Region: Glu 32 - Ala 547
• Purity: 95%
• Endotoxins: 0.01 EU per μg
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Expiration Date: 6 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

BCAM

RefSeq:P50895