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Catalog Number | orb1743041 |
---|---|
Category | Proteins |
Description | This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. |
Reactivity | Human |
Tag | C-10×His |
Form/Appearance | Liquid |
Purity | 90% |
Conjugation | Unconjugated |
MW | 55.3 kDa |
Target | ALPL |
Source | Human ALPL Protein, His Tag (orb1743041) is expressed from human 293 cells (HEK293). It contains AA Leu 18 - Ser 502 (Accession # P05186-1). |
Expression System | HEK293 |
Expression Region | Leu 18 - Ser 502 |
Endotoxins | 1.0 EU per μg |
Storage | -70°C |
Buffer/Preservatives | 20 mM Tris,150 mM NaCl,pH7.5 |
Note | For research use only |
Application notes | This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 55.3 kDa. The protein migrates as 65-70 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Expiration Date | 6 months from date of receipt. |
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