Huib32

SKU: orb3218129

Description

Huib32 is a potent small-molecule USP32 inhibitor with an IC50 of 21.2 nM and high selectivity over closely related deubiquitinases (DUBs) including USP8/10/16, UCHL1, and OTUB2. It inhibits USP32 via reversible covalent binding to the active site Cys743, thereby increasing substrate ubiquitination, altering endosomal morphology, and producing biological phenotypes similar to USP32 knockout. It can be used in research on breast cancer, ovarian cancer, lung cancer, Alzheimer’s disease, Parkinson’s disease, and other diseases.

Key Properties

• MW: 381.45
• Purity: 99.65% (May vary between batches)
• Formula: C₁₆H₂₃N₅O₄S
• SMILES: O=S(N1CCC(C(N[C@@H]2CCN(C#N)C2)=O)CC1)(C3=C(C)ON=C3C)=O
• Target: DUB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DUB