HUHS-015

SKU: orb1226243

Description

HUHS-015 (HUHS015) is a potent, orally active prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitor with IC50 of 0.67 uM; significantly suppresses the growth of DU145 cells in vitro and in a mouse xenograft model.

Key Properties

• CAS Number: 1453097-13-6
• MW: 318.3724
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈N₄O
• SMILES: OC1=C(CC2=CC=CC=C2)C(C)=NN1C3=NC4=CC(C)=CC=C4N3
• Target: DNA Repair Protein
• Solubility: DMSO: ≥ 34 mg/mL

Bioactivity

• In Vivo:
  HUHS015 potently suppresses the growth of DU145 cells in a mouse xenograft model. HUHS015 displays 7.2% bioavailability (BA) in rats after oral administration. Animal model: Nude mice. Dosage: 32 mg/kg. Administration: Subcutaneous injection; daily; 6 days. Result: Has inhibitory effect on the growth of subcutaneously implanted DU145, without limiting weight gains after a 6 days continuous administration.
• In Vitro:
  HUHS015 significantly suppresses the growth of DU145 cells, which are human hormone-independent prostate cancer cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HUHS015

Quick Database Links

Gene Symbol

DNA Repair Protein