Hu7691 free base

SKU: orb1691096

Description

Hu7691 free base is a potent, orally bioavailable, and selective pan-Akt inhibitor. It demonstrates anti-proliferative and differentiation-inducing effects in neuroblastoma cell lines in vitro, making it a valuable research tool for studying Akt signaling in oncology and neurobiology.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2241232-43-7
• MW: 414.423
• Purity: 98.89% (May vary between batches)
• Formula: C₂₂H₂₁F₃N₄O
• SMILES: N(C(=O)C1=C(F)C=C(C=C1)C2=CC=NN2C)[C@H]3[C@@H](CCNC3)C4=CC(F)=C(F)C=C4
• Target: PKA,SGK,Akt,PKC,ROCK,S6 Kinase

Bioactivity

• Target IC50:
  Akt3:28 nM (IC50)|ROCK1:354 nM (IC50)|ROCK1:354 nM|p70 S6K:229 nM (IC50)|PKCη:629 nM (IC50)|PKCη:629 nM|AKT2:97.5 nM|AKT1:4.0 nM|Akt2:97.5 nM (IC50)|PKA:11 nM|AKT3:28 nM|RSK1:756 nM (IC50)|RSK1:756 nM|Akt1:4.0 nM (IC50)|mTOR (p70S6K):229 nM|PKA:11 nM (IC50)
• In Vivo:
  In Balb/c mice (nu/nu, female, 3-4 weeks old, 20-25 g), Hu7691 free base (12.5, 25, 50 mg/kg; oral; once daily for 22 days) exhibited dose-dependent inhibition of tumor growth.
• In Vitro:
  In HaCaT cells, Hu7691 free base (2.25, 4.5, 9, 18, 36 μM; 24 hours) effectively induces a decrease in the phosphorylation level of Akt (S473).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Akt, Hu7691, Hu7691 free base, Hu-7691 free base

Compound Identifiers

PubChem CID

135274950