HTS05585

SKU: orb3135169

Description

HTS05585 (Compound Hit-1) is a selective inhibitor of macrophage migration inhibitory factor (MIF) with a Kd value of 0.29 μM determined by microscale thermophoresis (MST) and confirmed through isothermal titration calorimetry (ITC) at 0.32 μM. It suppresses the release of pro-inflammatory factors (TNF-α, IL-6, IL-1β) in macrophages induced by LPS, making it a promising candidate for the study of inflammatory diseases such as sepsis.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 696643-14-8
• MW: 289.33
• Formula: C₁₈H₁₅N₃O
• SMILES: N=1OC(=CC1C=2C=CC=CC2)C=3N=C4C=C(C=CN4C3)CC
• Target: MIF

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MIF