Hsp90-Cdc37-IN-4

SKU: orb3135099

Description

Hsp90-Cdc37-IN-4 is a novel derivative of triptolide that inhibits the protein-protein interaction (PPI) between Hsp90 and Cdc37. It selectively inhibits casein kinase 2 (CK 2), reducing the phosphorylation of its substrate Cdc37 at the serine 13 site. Additionally, Hsp90-Cdc37-IN-4 induces cell cycle arrest in the G0/G1 phase and triggers apoptosis via the mitochondrial pathway. This compound exhibits significant anti-breast cancer activity.

Research Area

Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2758818-41-4
• MW: 638.84
• Formula: C₄₀H₅₀N₂O₅
• SMILES: C[C@@]12[C@](C)([C@]3([C@@](C)(CC1)CC[C@](C(NCCCOC(/C=C/C4=CC=CC=N4)=O)=O)(C)C3)[H])CC[C@]5(C)C2=CC=C6C5=CC(=O)C(O)=C6C
• Target: Casein Kinase,Apoptosis,HSP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Casein Kinase,Apoptosis,HSP