HSN748

SKU: orb2945692

Description

HSN748 is a ponatinib analog and multi-kinase inhibitor targeting FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. It demonstrates efficacy in suppressing the proliferation of both chronic and acute myeloid leukemia cell lines in vitro, supporting its use as a research tool in leukemia studies.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2409925-53-5
• MW: 519.521
• Formula: C₂₇H₂₄F₃N₇O
• SMILES: O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCN(C)CC2)C=3C=NC=C(C#CC4=CN=C5C=CC=NN45)C3
• Target: c-RET,Bcr-Abl,MNK,FLT,PDGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146476029