hSMG-1 inhibitor 11j

SKU: orb1298552

Description

hSMG-1 inhibitor 11j

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1402452-15-6
• MW: 566.07
• Purity: 99.65%
• Formula: C₂₇H₂₈ClN₇O₃S
• SMILES: CCN(CC)S(=O)(=O)c1cc(Nc2nccc(n2)-c2ccnc(c2)-c2ccc(NC(=O)NC)cc2)ccc1Cl
• Target: PI3K,CDK,mTOR,GSK-3
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.83 mM);DMSO:70 mg/mL (123.66 mM)

Bioactivity

• Target IC50:
  PI3Kα:92 nM|SMG-1 (human):0.11 nM|CDK2:7.1 μM|mTOR:50 nM|PI3Kγ:60 nM|CDK1:32 μM|GSK-3α:260|GSK-3β:330
• In Vitro:
  hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM and eliminates it at 1 μM in MDA 361 cells. It also inhibits MDA468 cell proliferation with an IC50 of 75 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

mTOR, hSMG 1 inhibitor 11j, hSMG1 inhibitor 11j, hSMG-1 inhibitor 11j, PI3Kα/PI3Kγ

Compound Identifiers

PubChem CID

71458575