hSMG-1 inhibitor 11j

SKU: orb1298552

Description

hSMG-1 inhibitor 11j is a highly potent and selective pyrimidine-based small molecule targeting hSMG-1 kinase (IC50 = 0.11 nM). It demonstrates significant selectivity over related kinases like mTOR and PI3K and is utilized in cancer research for investigating DNA damage response pathways in cellular models.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1402452-15-6
• MW: 566.07
• Purity: 99.65%
• Formula: C₂₇H₂₈ClN₇O₃S
• SMILES: CCN(CC)S(=O)(=O)c1cc(Nc2nccc(n2)-c2ccnc(c2)-c2ccc(NC(=O)NC)cc2)ccc1Cl
• Target: PI3K,CDK,mTOR,GSK-3
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (8.83 mM);DMSO:70 mg/mL (123.66 mM)

Bioactivity

• Target IC50:
  PI3Kα:92 nM|SMG-1 (human):0.11 nM|CDK2:7.1 μM|mTOR:50 nM|PI3Kγ:60 nM|CDK1:32 μM|GSK-3α:260|GSK-3β:330
• In Vitro:
  hSMG-1 inhibitor 11j (0.3-3 μM; 6 h) significantly reduces UPF1 phosphorylation at 0.3 μM and eliminates it at 1 μM in MDA 361 cells. It also inhibits MDA468 cell proliferation with an IC50 of 75 nM .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTOR, hSMG 1 inhibitor 11j, hSMG1 inhibitor 11j, hSMG-1 inhibitor 11j, PI3Kα/PI3Kγ

Compound Identifiers

PubChem CID

71458575