HSD-016

SKU: orb1686471

Description

HSD-016 is a potent and selective oral inhibitor of 11β-HSD1, effective across human, mouse, and rat enzymes. It is a valuable research tool for investigating the role of 11β-HSD1 in preclinical models of diabetes, metabolic syndrome, and related metabolic disorders.

Research Area

Metabolism Research

Key Properties

• CAS Number: 946396-92-5
• MW: 514.46
• Purity: >99.99% (May vary between batches)
• Formula: C₂₁H₂₁F₇N₂O₃S
• SMILES: C[C@@H]1CN(CCN1S(=O)(=O)c1cccc(c1)[C@@](C)(O)C(F)(F)F)c1ccc(F)cc1C(F)(F)F
• Target: Dehydrogenase
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (6.41 mM);DMSO:80 mg/mL (155.5 mM)

Bioactivity

• Target IC50:
  11β-HSD1 (human):11 nM|11β-HSD1 (mouse):1 nM|11β-HSD1 (rat):8 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

11β-HSD1

Compound Identifiers

PubChem CID

16721125