HSB401

SKU: orb3174550

Description

HSB401 is an orally active FLT3 inhibitor with IC50 values of 28, 5, 72, and 51 nM for FLT3-WT, FLT3-D835Y, FLT3-ITD-F691L, and FLT3-ITD, respectively. It downregulates the FLT3 signaling pathway, inducing cell cycle arrest and apoptosis. HSB401 does not inhibit c-KIT, which reduces the risk of bone marrow suppression. In the MV4-11 xenograft mouse model, HSB401 significantly suppresses tumor growth and is applicable for research in acute myeloid leukemia (AML).

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3022265-51-3
• MW: 445.54
• Formula: C₂₆H₂₈FN₅O
• SMILES: O=C(NCCN(C)C)C1=CC=C(C(F)=C1)C=2N=C3C=CC=4NN=C(C4C3=C5C2CCCC5)C
• Target: Apoptosis,FLT

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,FLT