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HS-276 formic

SKU: orb3210952

Description

HS-276 formic is an orally active and highly selective TAK1 inhibitor with a Ki of 2.5 nM. It effectively inhibits TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. Additionally, HS-276 formic reduces the expression of TNF, IL-6, and IL-1β, making it valuable for rheumatoid arthritis (RA) research.

Images & Validation

Key Properties

TargetInterleukin,Casein Kinase,TNF,IRAK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information