HS-1793

SKU: orb1298480

Description

HS-1793

Research Area

Cell Biology

Key Properties

• CAS Number: 927885-00-5
• MW: 252.26
• Purity: 99.86%
• Formula: C₁₆H₁₂O₃
• SMILES: Oc1ccc(c(O)c1)-c1ccc2cc(O)ccc2c1
• Target: Apoptosis,Others
• Solubility: DMSO:22.5 mg/mL (89.19 mM)

Bioactivity

• In Vivo:
  HS-1793 significantly suppressed the growth of breast cancer tumor xenografts, without any apparent toxicity. Additionally, decreases in Ki-67, a proliferation index marker, and CD31, a biomarker of microvessel density, were observed in the tumor tissue. Expression of HIF-1 and VEGF was also downregulated in xenograft tumors treated with HS-1793. These in vivo results reinforce the improved anticancer activity of HS-1793 when compared with that of resveratrol. Overall, the present study suggests that the synthetic resveratrol analogue HS-1793 is a potent antitumor agent that inhibits tumor growth via the regulation of HIF-1, and demonstrates significant therapeutic potential for solid cancers.
• In Vitro:
  HS-1793 was found to inhibit hypoxia (1.0% oxygen)-induced HIF-1α expression at the protein level, and its inhibitory effect was more potent than that of resveratrol in MCF-7 and MDA-MB-231 breast cancer cells. Furthermore, HS-1793 reduced the secretion and mRNA expression of vascular endothelial growth factor (VEGF), a key mediator of HIF-1-driven angiogenesis, without affecting cell viability.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Akt, colon cancer, breast cancer, ERK, HCT116, MCF-7, HIF-1α, HS 1793, HS1793, HS-1793, inhibit, Inhibitor, resveratrol, VEGF

Compound Identifiers

PubChem CID

16215105