HRS 4642

SKU: orb2646170

Description

HRS 4642 is a potent and selective long-acting KRAS G12D inhibitor (Kd = 0.083 nM) that blocks MEK/ERK signaling, demonstrating antitumor efficacy in research models. It reduces tumor burden and, alone or combined with agents like Carfilzomib, promotes an immunocompetent tumor microenvironment in preclinical studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2836263-09-1
• MW: 632.68
• Purity: 99.17%
• Formula: C₃₄H₃₅F₃N₆O₃
• SMILES: C(OC=1N=C2C3=C(N1)C(F)=C(N=C3OC[C@]4(N2C[C@@]5(N[C@]4(CC5)[H])[H])[H])C=6C7=C(C=CC(F)=C7CC)C=C(O)C6)[C@@]89N(C[C@H](F)C8)CCC9
• Target: MEK,ERK,Ras,Kras
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:5 mg/mL (7.9 mM);DMSO:≥ 80 mg/mL

Bioactivity

• Target IC50:
  KRas (G12D):0.083 nM (Ki)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HRS4642, HRS-4642

Compound Identifiers

PubChem CID

171853615