HR68

• Catalog Number: orb1979954
• Category: Small Molecules
• Description: HR68, a derivative of the peroxisome proliferator-activated receptor (PPAR) agonist fenofibric acid, serves as an anticancer agent. It effectively reduces the viability of LN-229 glioblastoma cells, with an IC50 value of 1.17 µM. Notably, HR68 is capable of crossing the blood-brain barrier in temozolomide-resistant orthotopic patient-derived xenograft (PDX) mouse models of glioblastoma.
• Purity: 98.00%
• MW: 394.85
• Biological Activity: HR68, a derivative of the peroxisome proliferator-activated receptor (PPAR) agonist fenofibric acid, serves as an anticancer agent. It effectively reduces the viability of LN-229 glioblastoma cells, with an IC50 value of 1.17 µM. Notably, HR68 is capable of crossing the blood-brain barrier in temozolomide-resistant orthotopic patient-derived xenograft (PDX) mouse models of glioblastoma.
• CAS Number: 2454582-64-8
• Formula: C₂₂H₁₉ClN₂O₃
• SMILES: CC(C(NC1=CC=NC=C1)=O)(OC2=CC=C(C(C3=CC=C(C=C3)Cl)=O)C=C2)C
• Storage: -20°C
• Note: For research use only