HQY1428

SKU: orb3027518

Description

HQY1428 is an orally active CDK12 inhibitor. It impedes DNA replication, causing cell cycle arrest at the G2/M phase in SKOV3 cells, and induces DNA double-strand breaks as well as apoptosis. In the SKOV3 xenograft mouse model, HQY1428 demonstrates antitumor activity. Additionally, when combined with the HER2 inhibitor Lapatinib in the NCI-N87 xenograft mouse model, HQY1428 produces a synergistic therapeutic effect.

Research Area

Cell Biology, Molecular Biology

Key Properties

• Formula: C₂₅H₂₈ClFN₆O₃S
• Target: Apoptosis,DNA/RNA Synthesis,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Apoptosis,DNA/RNA Synthesis,CDK