HPK1-IN-69

SKU: orb3211154

Description

HPK1-IN-69 is an orally active HPK1 inhibitor with an IC50 of 1.7 nM. It inhibits the HPK1-mediated TCR signaling pathway, reduces phosphorylation levels of SLP76, and promotes the release of IL-2. In mouse models, HPK1-IN-69 exhibits in vivo antitumor activity. This compound is applicable for research on colorectal cancer and MC38 syngeneic tumors.

Key Properties

• CAS Number: 3095423-83-6
• MW: 416.48
• Formula: C₂₂H₂₄N₈O
• SMILES: N#CC1=CC(=CC=C1N2CCN(C)CC2)C3=NC(OCC=4C=CN=C(N)C4)=C(N=C3)N
• Target: MAPK,Interleukin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MAPK,Interleukin