HPK1-IN-68

SKU: orb3210804

Description

HPK1-IN-68 (Compound 39) is an HPK1 inhibitor with an IC50 of 2.8 nM. It effectively blocks HPK1 signaling, impedes HPK1-mediated SLP76 phosphorylation, and enhances IL-2 cytokine production. Additionally, HPK1-IN-68 counteracts PGE2-mediated immunosuppression and promotes infiltration of CD3+/CD8+ T cells into tumor tissue. It demonstrates T cell-dependent antitumor efficacy in a mouse colon cancer model and shows significant synergistic antitumor effects when combined with anti-PD-1 therapy. HPK1-IN-68 is applicable for research related to colon cancer.

Key Properties

• CAS Number: 3078477-58-1
• MW: 453.51
• Formula: C₂₃H₂₈FN₇O₂
• SMILES: NC=1C(=NC(=CN1)C2=CC(C)=C(OCCCN3C[C@@H](F)CC3)C(C)=C2)N4C=C(C(N)=O)C=N4
• Target: Interleukin,MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,MAPK