HPK1-IN-65

SKU: orb3174324

Description

HPK1-IN-65 is a selective, orally active HPK1 inhibitor with an IC50 value of less than 5 nM, demonstrating 1257-fold selectivity over the MAP4K kinase family member GLK. It inhibits pSLP76 phosphorylation with an IC50 of 92.3 nM and stimulates IL-2 production with an EC50 of 398 nM. Additionally, HPK1-IN-65 suppresses the phosphorylation of the TCR-induced SLP76Ser376 site in a dose-dependent manner. This compound is also applicable in colon cancer research.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• Target: Interleukin,MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Interleukin,MAPK