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HPK1-IN-62

SKU: orb3173251

Description

HPK1-IN-62 is a selective, orally active inhibitor of HPK-1 with an IC50 of 1.22 nM. It significantly enhances selectivity for GLK (> 665-fold) and LCK (> 1095-fold). HPK1-IN-62 boosts T cell activation and shows synergy with anti-mPD-1 therapy in inhibiting tumor growth in the MC38 tumor model. It is applicable for research in colon cancer and cancer immunotherapy.

Research Area

Signal Transduction

Images & Validation

Key Properties

TargetMAPK

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information