HPK1-IN-4

SKU: orb1690645

Description

HPK1-IN-4 is a potent and selective preclinical inhibitor of hematopoietic progenitor kinase 1 (HPK1/MAP4K1) with an IC50 of 0.061 nM. This tool compound is utilized in immunological research to investigate HPK1's role in T-cell signaling and function, supporting both in vitro cellular assays and in vivo efficacy studies in preclinical cancer immunotherapy models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2739844-28-9
• MW: 434.49
• Purity: 97.20% (May vary between batches)
• Formula: C₂₃H₂₆N₆O₃
• SMILES: COc1cc2CCN(C)Cc2cc1Nc1ncc(C(N)=O)c(Nc2ccccc2CO)n1
• Target: MAPK
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.3 mM);DMSO:90 mg/mL (207.14 mM)

Bioactivity

• Target IC50:
  HPK1:0.061 nM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MAP4K, HPK1IN4, HPK-1-IN-4, HPK1-IN-4, HPK1, HPK1 IN 4

Compound Identifiers

PubChem CID

155925915