HPK1-IN-34

SKU: orb2813892

Description

HPK1-IN-34 (Compound 143) is a potent small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1), demonstrating an IC₅₀ value below 0.1 µM. This compound is a valuable research tool for investigating HPK1 signaling in oncology and immunology, supporting both in vitro cellular studies and in vivo preclinical research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2380300-99-0
• MW: 448.58
• Purity: 99.39% (May vary between batches)
• Formula: C₂₅H₂₈N₄O₂S
• SMILES: OC(C#CC1=CC=CC(=C1)COC=2C=C(C=NC2N)C=3SC(=NC3)C4CCNCC4)(C)C
• Target: Others,MAPK
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (4.46 mM);DMSO:20 mg/mL (44.59 mM)

Bioactivity

• Target IC50:
  HPK1:<100 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156214993