HPK1-IN-33

SKU: orb1744397

Description

HPK1-IN-33 (compound 21) is a potent and selective HPK1 inhibitor with a K_i of 1.7 nM. It demonstrates functional activity by inhibiting IL-2 production in Jurkat WT cells (EC_50 = 286 nM), an effect absent in HPK1 KO cells. This inhibitor is a valuable tool for probing HPK1's role in T-cell signaling and immune regulation in both cellular and in vivo research contexts.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2920000-86-6
• MW: 370.81
• Formula: C₁₈H₁₆ClFN₆
• SMILES: N#Cc1cccc(-c2c(Cl)[nH]c3ncnc(N4CC[C@@H](F)[C@@H](N)C4)c23)c1
• Target: MAPK,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168007152