HPi1

SKU: orb1308223

Description

HPi1

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 13080-21-2
• MW: 192.24
• Purity: 98.80%
• Formula: C₈H₈N₄S
• SMILES: NNC1=NC2=CC=CC=C2NC1=S
• Target: Antibacterial
• Solubility: DMSO:60 mg/mL (312.11 mM);10% DMSO+90% Saline:2.5 mg/mL (13 mM)

Bioactivity

• Target IC50:
  Antibacterial:(MIC)0.08-0.16 μg/ml(Helicobacter pylori)|Antibacterial:0.24 μM
• In Vivo:
  Treated with HPi1 (6.25-50 mg/kg; Oral gavage; once a day; for 3 days; female C57BL/6 mice), reduces colony counts below the limit of detection at doses of 25 or 50 mg/kg/day.
• In Vitro:
  HPi1 demonstrates efficacy against clarithromycin-resistant H. pylori strains ARHp172 (with a minimum inhibitory concentration (MIC) of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL). Although HPi1 is somewhat effective against Bacteroides species, the required concentration is significantly higher (at least 18 times) than for inhibiting H. pylori. The compound possesses favorable physicochemical and pharmacological characteristics, including an aqueous solubility of 19 μg/mL, 93% human plasma protein binding, a half-life of 1.3 hours in the presence of human liver microsomes, and the capacity for passive membrane permeation. Its MIC values against various H. pylori isolates range from 0.002 to 0.032 μg/mL (0.01 to 0.17 μM) according to agar dilution assays, indicating broad activity. Additionally, HPi1 exhibits even stronger activity against Campylobacter jejuni, with a MIC of 0.3 μg/mL.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Helicobacter, Helicobacter pylori, Inhibitor, gastric, membranes, HPi1, HPi-1, HPi 1, inhibit, orally, Antimicrobial, Bacterial, permeate, pylori, peptic, ulcer

Compound Identifiers

PubChem CID

781248