HPI-1 (hydrate)

• Catalog Number: orb1694530
• Category: Small Molecules
• Description: HPI-1 (hydrate)
• Purity: 98.00%
• MW: 481.54
• Biological Activity: HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1
• CAS Number: 1262770-72-8
• Formula: C₂₇H₃₁NO₇
• SMILES: O=C(OCCOC)C1=C(NC2=C(C(=O)CC(C=3C=CC=CC3OC)C2)C1C=4C=CC=C(O)C4)C.O
• Storage: -20°C
• Note: For research use only