HP661

SKU: orb1980000

Description

HP661 is a potent and selective mitochondrial complex I inhibitor that reduces viability in OXPHOS-high lung cancer cells (e.g., H460, A549) with nanomolar IC50s while sparing low-OXPHOS cells. It demonstrates significant in vivo antitumor activity in an H460 xenograft model and synergizes with trametinib, supporting its use in cancer metabolism and therapy resistance research.

Key Properties

• MW: 661.60
• Formula: C₃₁H₂₉F₆N₇O₃
• SMILES: FC(F)(F)C1=CC=C(NC(C2=CC=C(CN3N=NC(C(N4CCN(CC5=CC=C(OCC(F)(F)F)C=C5)CC4)=O)=C3C)C=N2)=O)C=C1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

170901597